There are advantages and disadvantages to both
yes, there is, but if you stay in one spot, thene just let thousands or even millions be outside of your safehouse what the hell do you do next? save a bullet, my guss, thats what id do, just incase. other than that, yea, theres many different senarios that can be put into what would hapen, but if your smart, moveing along the roads, stoping at towns, getting supplies, mabey even a gass hauler. its better thene to let yourself be sitting ducks. mabey stay there for a night, thene keep oveing. but yes, if the vechial dose break down in a dessart, or there are hordes of undead blocking your way, you kind of are a gonner.